the science behind brainsparx13

Cognitive performance, focus, and long-term brain health aren’t just matters of lifestyle — they’re deeply influenced by the nutrients we consume. The brain depends on vitamins and minerals to regulate neurotransmitters, protect against oxidative stress, and maintain energy production. This page presents the science behind some of the key ingredients in brainsparx13, supported by peer-reviewed studies.

Zinc

Zinc is crucial for neurotransmission, brain development, and protecting against cognitive decline. Research shows that deficiency can impair mental performance and neurological function. Li et al. (2022) highlight zinc’s wide-ranging impact on health, while Constantinidis (1992) demonstrated zinc compounds’ potential role in treating Alzheimer’s disease.

• Li, J. et al. (2022). Zinc Intakes and Health Outcomes: An Umbrella Review. Frontiers in Nutrition
• Constantinidis, J. (1992). Treatment of Alzheimer’s Disease by Zinc Compounds. Drugs Development Research, 27(1), 1–14.
• Prasad, A. (1983). Clinical biochemical and nutritional spectrum of zinc deficiency in humans. Nutrition Reviews, 41, 197–208.

Vitamin D3

Vitamin D3 plays an essential role in mood regulation, immune function, and brain health. Consensus guidelines from Giustina et al. (2024) emphasize the importance of supplementation, while Koeffler and Norman (1989) highlighted its role in the endocrine system and disease prevention.

• Giustina, A. et al. (2024). Consensus Statement on Vitamin D Status Assessment and Supplementation. Endocrine Reviews
• Koeffler, H., Reichel, H., Norman, A.W. (1989). The Role of the Vitamin D Endocrine System in Health and Disease. NEJM, 320, 980–981.

Vitamin B6

Vitamin B6 supports neurotransmitter synthesis, helping regulate mood and cognitive clarity. Stach et al. (2021) reviewed its role across health and disease, while Driskell (1964) examined human requirements.

• Stach, K. et al. (2021). Vitamin B6 in Health and Disease. Nutrients.
• Driskell, J.A. (1964). Vitamin B6 Requirements of Humans. Nutrition Research, 14, 293–324.

Magnesium

Magnesium is essential for over 300 enzymatic processes, including those governing nerve signaling and energy metabolism. Witteman et al. (1994) and Montoya et al. (1989) demonstrated magnesium’s ability to reduce blood pressure, suggesting broader vascular and brain-protective effects.

• Witteman, J.C.M. et al. (1994). Reduction of blood pressure with oral magnesium supplementation in women. AJCN, 60, 129–1351.
• Montoya, T., Sano, H., Fukuzaki, H. (1989). Oral magnesium supplementation in patients with essential hypertension. Circulation, 13, 227–232.

Folate (5-MTHF)

Folate in its active form, 5-MTHF, is vital for DNA synthesis, methylation, and reducing homocysteine levels, which are linked to vascular and cognitive decline.

• Bailey, L.B. (1995). Folate in Health and Disease. Marcel Dekker.
• Clarke, R. et al. (1991). Hyperhomocysteinemia, an independent risk factor in vascular disease. NEJM, 324, 1149–1155.
• Glueck, C.J. et al. (1995). Homocysteine as an independent factor for atherosclerosis in hyperlipidemia patients. Am J Cardiology, 75, 132–136.

Vitamin B12

Vitamin B12 plays a key role in nerve protection, red blood cell formation, and energy metabolism. Deficiency is linked to fatigue, depression, and neurological impairment. Markun et al. (2021) provided evidence of B12 supplementation improving cognitive and mood-related symptoms, while Van Goor et al. (1995) confirmed its role in preventing mental decline in the elderly.

• Lederle, F.A. (1991). Oral Cobalamin for Pernicious Anemia. JAMA, 265, 94–95.
• Van Goor, L. et al. (1995). Cobalamin deficiency and mental impairment in elderly people. Age & Ageing, 24(6), 536–42.
• Ubbink, J.B. et al. (1993). Vitamin B12, Vitamin B6 and Folate status in men with hyperhomocysteinemia. AJCN, 57, 47–53.
• Markun, S. et al. (2021). Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue. Nutrients.

Vitamin B2 (Riboflavin)

Riboflavin supports mitochondrial energy production and helps regulate homocysteine metabolism in combination with B12 and folate. Manios et al. (2017) observed that B2 intake was closely associated with homocysteine regulation in children, underlining its long-term importance.

• Peechakara, B.V. (2025). Vitamin B2 (Riboflavin). Stat Publishing LLC.
• Manios, Y. et al. (2017). Vitamin B2, Vitamin B12 and total homocysteine status in children. Eur J Nutr.

conclusion

The ingredients in brainsparx13 were selected because they’re not just vitamins and minerals — they are scientifically validated compounds that contribute directly to mental performance, energy, and long-term cognitive protection. From neurotransmitter synthesis (B6, B12, folate) to mitochondrial function (riboflavin, magnesium) and neuroprotection (zinc, vitamin D3), each element is backed by decades of research. brainsparx13 brings them together in one synergistic formula designed to elevate clarity, focus, and resilience.